Why Am I Sleeping So Poorly on a GLP-1 Medication?

Poor sleep is a common but often overlooked side effect of GLP-1 medications like semaglutide or tirzepatide. As your body adjusts to changes in appetite, digestion, and blood sugar regulation, you may experience nighttime discomfort, restlessness, or even increased anxiety. Slower gastric emptying can leave you feeling overly full at bedtime, while hormonal shifts and reduced caloric intake may disrupt your natural sleep-wake cycle. Fortunately, these sleep issues are often temporary and can be managed with simple adjustments to your routine, like changing the timing of your dose, avoiding late meals, and ensuring you’re getting enough nutrients to support restful sleep.