Why Your Period Changes on GLP-1s (and When to Be Concerned)
If you’ve noticed changes in your period since starting GLP-1 medications like semaglutide or tirzepatide, you’re not alone. These medications are powerful tools for weight loss and blood sugar control—but they can also cause some surprising changes in your menstrual cycle. Let’s break it down simply and clearly.
Why Do Periods Change on GLP-1s?
GLP-1 medications affect more than just your weight. They impact your hormones, digestion, stress levels, and metabolism—all of which can influence your cycle.
Here are a few reasons your period might shift:
1. Weight Loss and Hormones: Rapid weight loss can change how your body produces estrogen and progesterone. When fat cells shrink, they release hormones differently, and this can lead to lighter, heavier, shorter, or longer periods.
2. Improved Insulin Sensitivity: GLP-1s help your body use insulin more efficiently. For people with PCOS or insulin resistance, this can help regulate previously irregular cycles—but it can also take time for your body to adjust.
3. Stress and Cortisol: Any big lifestyle change—including medication, eating habits, or weight loss—can raise stress hormones like cortisol. Cortisol can delay or disrupt your period, especially in the first few months of treatment.
Common Period Changes You Might See
Missed or delayed periods
Heavier or lighter flow
Shorter or longer cycles
More cramping or less cramping
These changes are often temporary and improve as your body gets used to the medication and your new routine.
When to Be Concerned
While many period changes are normal during weight loss, there are times to check in with a provider:
You’ve missed three or more periods in a row
Your bleeding is unusually heavy or painful
You experience spotting for more than a few days between periods
You think you might be pregnant
You have a history of hormone imbalance or reproductive health issues
Remember: GLP-1s are powerful, but they’re not one-size-fits-all. Everybody responds differently.
What You Can Do
Track your cycle using an app or journal
Stay hydrated and eat regularly to support hormone balance
Reduce stress with activities like walking, journaling, or yoga
Talk to your care team if you’re worried—there may be simple adjustments that can help
You Don’t Have to Figure This Out Alone
At Core Aesthetics, we offer more than just a prescription. Our team supports you through the whole process—hormonal shifts, emotional changes, and everything in between.
👉 Book a consultation today to get the answers—and support—you deserve.
